By Andrew Franklin
During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a method known as affinity maturation. a bunch produces antibodies with successively higher affinities with repeated publicity to an identical antigen, that's the primary through which so much vaccines work.
Affinity maturation depends on hypermutation, an iterative strategy of mutation at antibody-encoding genes, via optimistic number of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation may end up in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant step forward got here in 2000 with the invention that activation-induced deaminase (AID) is basically required for hypermutation. This was once in 2002 via proof that relief at once edits the DNA that encodes an antibody in an activated B mobile. a lot has on the grounds that been learnt concerning the biochemistry and law of reduction, however the mechanism through which it really is recruited in particular to antibody-encoding genes is still enigmatic. figuring out this recruitment is clinically major simply because off-target relief task at oncogenes can result in chromosomal translocations and tumorigenesis.
This e-book summarizes the examine on reduction within the context of its relevant position within the affinity maturation of B cells.
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Extra resources for Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci
Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin